One misfortune rides upon another's back|I lost my job yesterday, and I got hit by a car this morning.  Oh... one misfortune rides upon other's back.
One thing at a time|Hey, I am not a superman.  I can only handle one thing at a time, Okay?
Something you should know|Mary, I don't know how to say this, but there's something you should know.  Alex got married today.
Sometimes you win, sometimes you lose|Take it easy, Alex, you know, life is not always full of fun.  Sometimes you win, sometimes you lose.
That's final|I will pay $90 for this flash design, and that's final.
tied up|I am really sorry.  I am tied up this morning, can you call back this afternoon?
brand new|Alex just bought a brand new car.
bottom of my heart|I love her from the bottom of my heart.